TNFA-863 polymorphism is associated with a reduced risk of chronic obstructive pulmonary disease: a replication study.

ABSTRACT:

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Background

TNF-α mediated inflammation is thought to play a key role in the respiratory and systemic features of Chronic Obstructive Pulmonary Disease. The aim of the present study was to replicate and extend recent findings in Taiwanese and Caucasian populations of associations between COPD susceptibility and variants of the TNFA gene in a Spanish cohort.

Methods

The 3 reported SNPs were complemented with nine tag single nucleotide polymorphisms (SNP) of the TNFA and LTA genes and genotyped in 724 individuals (202 COPD patients, 90 smokers without COPD and 432 healthy controls). Pulmonary function parameters and serum inflammatory markers were also measured in COPD patients.

Results

The TNFA rs1800630 (-863C/A) SNP was associated with a lower COPD

SUBMITTER: Cordoba-Lanus E 

PROVIDER: S-EPMC3209447 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature