Whole genome expression in peripheral-blood samples of workers professionally exposed to polycyclic aromatic hydrocarbons.

ABSTRACT: This study aims to examine global gene expression profiles before and after the work-shift among coke-oven workers (COWs). COWs work six consecutive days and then take two days off. Two blood and urine samples in each worker were collected before starting to work after two days off and end-of-shift in the sixth day of work in 2009. Altered gene expressions (ratio of gene expression levels between end-of-shift and preshift work) were performed by a Human OneArray expression system which probes ~30,000-transcription expression profiling of human genes. Sixteen workers, all men, were enrolled in this study. Median urinary 1-hydroxypyrene (1OHP) levels (μmol/mol creatinine) in end-of-shift work were significantly higher than those in preshift work (2.58 vs 0.29, p = 0.0002). Among the 20,341 g

SUBMITTER: Wu MT 

PROVIDER: S-EPMC3209535 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature