Prognostic effect size of cardiovascular biomarkers in datasets from observational studies versus randomised trials: meta-epidemiology study.

ABSTRACT:

Objective

To compare the reported effect sizes of cardiovascular biomarkers in datasets from observational studies with those in datasets from randomised controlled trials.

Design

Review of meta-analyses.

Study selection

Meta-analyses of emerging cardiovascular biomarkers (not part of the Framingham risk score) that included datasets from at least one observational study and at least one randomised controlled trial were identified through Medline (last update, January 2011).

Data extraction

Study-specific risk ratios were extracted from all identified meta-analyses and synthesised with random effects for (a) all studies, and (b) separately for observational and for randomised controlled trial populations for comparison.

Results

31 eligible meta-analyses

SUBMITTER: Tzoulaki I 

PROVIDER: S-EPMC3209745 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature