Analysis of genetic linkage of HIV from couples enrolled in the HIV Prevention Trials Network 052 trial.

ABSTRACT:

Background

The HIV Prevention Trials Network (HPTN) 052 trial demonstrated that early initiation of antiretroviral therapy (ART) reduces human immunodeficiency virus (HIV) transmission from HIV-infected adults (index participants) to their HIV-uninfected sexual partners. We analyzed HIV from 38 index-partner pairs and 80 unrelated index participants (controls) to assess the linkage of seroconversion events.

Methods

Linkage was assessed using phylogenetic analysis of HIV pol sequences and Bayesian analysis of genetic distances between pol sequences from index-partner pairs and controls. Selected samples were also analyzed using next-generation sequencing (env region).

Results

In 29 of the 38 (76.3%) cases analyzed, the index was the likely source of the partner's HIV i

SUBMITTER: Eshleman SH 

PROVIDER: S-EPMC3209811 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature