Gene expression profiling in the Cynomolgus macaque Macaca fascicularis shows variation within the normal birth range.

ABSTRACT:

Background

Although an adverse early-life environment has been linked to an increased risk of developing the metabolic syndrome, the molecular mechanisms underlying altered disease susceptibility as well as their relevance to humans are largely unknown. Importantly, emerging evidence suggests that these effects operate within the normal range of birth weights and involve mechanisms of developmental palsticity rather than pathology.

Method

To explore this further, we utilised a non-human primate model Macaca fascicularis (Cynomolgus macaque) which shares with humans the same progressive history of the metabolic syndrome. Using microarray we compared tissues from neonates in the average birth weight (50-75th centile) to those of lower birth weight (5-25th centile) and studied

SUBMITTER: Emerald BS 

PROVIDER: S-EPMC3210194 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature