Ontology highlight
ABSTRACT:
SUBMITTER: Chittuluru JR
PROVIDER: S-EPMC3210417 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20111009 11
We have used EM and biochemistry to characterize the structure of NuA4, an essential yeast histone acetyltransferase (HAT) complex conserved throughout eukaryotes, and we have determined the interaction of NuA4 with the nucleosome core particle (NCP). The ATM-related Tra1 subunit, which is shared with the SAGA coactivator complex, forms a large domain joined to a second region that accommodates the catalytic subcomplex Piccolo and other NuA4 subunits. EM analysis of a NuA4-NCP complex shows the ...[more]