FGF/EGF signaling regulates the renewal of early nephron progenitors during embryonic development.

ABSTRACT: Recent studies indicate that nephron progenitor cells of the embryonic kidney are arranged in a series of compartments of an increasing state of differentiation. The earliest progenitor compartment, distinguished by expression of CITED1, possesses greater capacity for renewal and differentiation than later compartments. Signaling events governing progression of nephron progenitor cells through stages of increasing differentiation are poorly understood, and their elucidation will provide key insights into normal and dysregulated nephrogenesis, as well as into regenerative processes that follow kidney injury. In this study, we found that the mouse CITED1(+) progenitor compartment is maintained in response to receptor tyrosine kinase (RTK) ligands that activate both FGF and EGF receptors. Thi

SUBMITTER: Brown AC 

PROVIDER: S-EPMC3210493 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature