A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.

ABSTRACT:

Background

Given moderately strong genetic contributions to variation in alcoholism and heaviness of drinking (50% to 60% heritability) with high correlation of genetic influences, we have conducted a quantitative trait genome-wide association study (GWAS) for phenotypes related to alcohol use and dependence.

Methods

Diagnostic interview and blood/buccal samples were obtained from sibships ascertained through the Australian Twin Registry. Genome-wide single nucleotide polymorphism (SNP) genotyping was performed with 8754 individuals (2062 alcohol-dependent cases) selected for informativeness for alcohol use disorder and associated quantitative traits. Family-based association tests were performed for alcohol dependence, dependence factor score, and heaviness of drinking fact

SUBMITTER: Heath AC 

PROVIDER: S-EPMC3210694 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature