Up-regulation of Th17 cells may underlie inhibition of Treg development caused by immunization with activated syngeneic T cells.

ABSTRACT:

Background

Our previous work showed that mice immunized with attenuated activated syngeneic T cells (aTCV) led to damping Treg function which resulted in enhancing anti-tumor immunity. It is well known that DC plays a very important role in controlling Th cell differentiation; whether DC involves Treg attenuation in immunized mice remained unknown. In this study, we provided evidence that increased mature DC (mDC) after immunization with aTCV skewed Th17 differentiation, which resulted in inhibition of Treg differentiation through IL-6 signaling pathway.

Principal findings

In the present study, we found that the frequency of mDCs increased dramatically in the immunized mice accompanied by lower Treg cells compared to the controls. Moreover, both DCs and serum derived from th

SUBMITTER: Wang L 

PROVIDER: S-EPMC3210778 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature