Progesterone receptor polymorphisms and clinical response to 17-alpha-hydroxyprogesterone caproate.

ABSTRACT:

Objective

Seventeen-alpha-hydroxyprogesterone caproate (17-OHPC) reduces recurrent preterm birth (PTB). We hypothesized that single nucleotide polymorphisms in the human progesterone receptor (PGR) affect response to 17-OHPC in the prevention of recurrent PTB.

Study design

We conducted secondary analysis of a study of 17-OHPC vs placebo for recurrent PTB prevention. Twenty PGR gene single nucleotide polymorphisms were studied. Multivariable logistic regression assessed for an interaction between PGR genotype and treatment status in modulating the risk of recurrent PTB.

Results

A total of 380 women were included; 253 (66.6%) received 17-OHPC and 127 (33.4%) received placebo. In all, 61.1% of women were African American. Multivariable logistic regression demonstrated si

SUBMITTER: Manuck TA 

PROVIDER: S-EPMC3210889 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature