Gene expression profile change and associated physiological and pathological effects in mouse liver induced by fasting and refeeding.

ABSTRACT: Food availability regulates basal metabolism and progression of many diseases, and liver plays an important role in these processes. The effects of food availability on digital gene expression profile, physiological and pathological functions in liver are yet to be further elucidated. In this study, we applied high-throughput sequencing technology to detect digital gene expression profile of mouse liver in fed, fasted and refed states. Totally 12162 genes were detected, and 2305 genes were significantly regulated by food availability. Biological process and pathway analysis showed that fasting mainly affected lipid and carboxylic acid metabolic processes in liver. Moreover, the genes regulated by fasting and refeeding in liver were mainly enriched in lipid metabolic process or fatty acid m

SUBMITTER: Zhang F 

PROVIDER: S-EPMC3212576 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature