The identification of gene expression profiles associated with progression of human diabetic neuropathy.

ABSTRACT: Diabetic neuropathy is a common complication of diabetes. While multiple pathways are implicated in the pathophysiology of diabetic neuropathy, there are no specific treatments and no means to predict diabetic neuropathy onset or progression. Here, we identify gene expression signatures related to diabetic neuropathy and develop computational classification models of diabetic neuropathy progression. Microarray experiments were performed on 50 samples of human sural nerves collected during a 52-week clinical trial. A series of bioinformatics analyses identified differentially expressed genes and their networks and biological pathways potentially responsible for the progression of diabetic neuropathy. We identified 532 differentially expressed genes between patient samples with progressing o

SUBMITTER: Hur J 

PROVIDER: S-EPMC3212712 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature