Neuropathological features of corticobasal degeneration presenting as corticobasal syndrome or Richardson syndrome.

ABSTRACT: Patients with corticobasal degeneration can present with several different clinical syndromes, making ante-mortem diagnosis a challenge. Corticobasal syndrome is the clinical phenotype originally described for corticobasal degeneration, characterized by asymmetric rigidity and apraxia, cortical sensory deficits, dystonia and myoclonus. Some patients do not develop these features, but instead have clinical features consistent with the Richardson syndrome presentation of progressive supranuclear palsy, characterized by postural instability, early unexplained falls, vertical supranuclear gaze palsy, symmetric motor disability and dysphagia. The aim of this study was to identify differences in corticobasal degeneration presenting with corticobasal syndrome (n = 11) or Richardson syndrome (n =

SUBMITTER: Kouri N 

PROVIDER: S-EPMC3212714 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature