Endothelial function is unaffected by changing between carvedilol and metoprolol in patients with heart failure--a randomized study.

ABSTRACT:

Background

Carvedilol has been shown to be superior to metoprolol tartrate to improve clinical outcomes in patients with heart failure (HF), yet the mechanisms responsible for these differences remain unclear. We examined if there were differences in endothelial function, insulin stimulated endothelial function, 24 hour ambulatory blood pressure and heart rate during treatment with carvedilol, metoprolol tartrate and metoprolol succinate in patients with HF.

Methods

Twenty-seven patients with mild HF, all initially treated with carvedilol, were randomized to a two-month treatment with carvedilol, metoprolol tartrate or metoprolol succinate. Venous occlusion plethysmography, 24-hour blood pressure and heart rate measurements were done before and after a two-month treatment pe

SUBMITTER: Falskov B 

PROVIDER: S-EPMC3212926 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature