Biological interaction networks are conserved at the module level.

ABSTRACT:

Background

Orthologous genes are highly conserved between closely related species and biological systems often utilize the same genes across different organisms. However, while sequence similarity often implies functional similarity, interaction data is not well conserved even for proteins with high sequence similarity. Several recent studies comparing high throughput data including expression, protein-protein, protein-DNA, and genetic interactions between close species show conservation at a much lower rate than expected.

Results

In this work we collected comprehensive high-throughput interaction datasets for four model organisms (S. cerevisiae, S. pombe, C. elegans, and D. melanogaster) and carried out systematic analyses in order to explain the apparent lower conservation

SUBMITTER: Zinman GE 

PROVIDER: S-EPMC3212960 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature