The Fur regulon in anaerobically grown Salmonella enterica sv. Typhimurium: identification of new Fur targets.

ABSTRACT:

Background

The Ferric uptake regulator (Fur) is a transcriptional regulator that controls iron homeostasis in bacteria. Although the regulatory role of Fur in Escherichia coli is well characterized, most of the studies were conducted under routine culture conditions, i.e., in ambient oxygen concentration. To reveal potentially novel aspects of the Fur regulon in Salmonella enterica serovar Typhimurium under oxygen conditions similar to that encountered in the host, we compared the transcriptional profiles of the virulent wild-type strain (ATCC 14028s) and its isogenic Δfur strain under anaerobic conditions.

Results

Microarray analysis of anaerobically grown Δfur S. Typhimurium identified 298 differentially expressed genes. Expression of several genes controlled by Fnr and Ns

SUBMITTER: Troxell B 

PROVIDER: S-EPMC3212961 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature