In-silico prediction of disorder content using hybrid sequence representation.

ABSTRACT:

Background

Intrinsically disordered proteins play important roles in various cellular activities and their prevalence was implicated in a number of human diseases. The knowledge of the content of the intrinsic disorder in proteins is useful for a variety of studies including estimation of the abundance of disorder in protein families, classes, and complete proteomes, and for the analysis of disorder-related protein functions. The above investigations currently utilize the disorder content derived from the per-residue disorder predictions. We show that these predictions may over-or under-predict the overall amount of disorder, which motivates development of novel tools for direct and accurate sequence-based prediction of the disorder content.

Results

We hypothesize that seque

SUBMITTER: Mizianty MJ 

PROVIDER: S-EPMC3212983 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature