A density-dependent switch drives stochastic clustering and polarization of signaling molecules.

ABSTRACT: Positive feedback plays a key role in the ability of signaling molecules to form highly localized clusters in the membrane or cytosol of cells. Such clustering can occur in the absence of localizing mechanisms such as pre-existing spatial cues, diffusional barriers, or molecular cross-linking. What prevents positive feedback from amplifying inevitable biological noise when an un-clustered "off" state is desired? And, what limits the spread of clusters when an "on" state is desired? Here, we show that a minimal positive feedback circuit provides the general principle for both suppressing and amplifying noise: below a critical density of signaling molecules, clustering switches off; above this threshold, highly localized clusters are recurrently generated. Clustering occurs only in the stoch

SUBMITTER: Jilkine A 

PROVIDER: S-EPMC3213192 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature