ATAQS: A computational software tool for high throughput transition optimization and validation for selected reaction monitoring mass spectrometry.

ABSTRACT:

Background

Since its inception, proteomics has essentially operated in a discovery mode with the goal of identifying and quantifying the maximal number of proteins in a sample. Increasingly, proteomic measurements are also supporting hypothesis-driven studies, in which a predetermined set of proteins is consistently detected and quantified in multiple samples. Selected reaction monitoring (SRM) is a targeted mass spectrometric technique that supports the detection and quantification of specific proteins in complex samples at high sensitivity and reproducibility. Here, we describe ATAQS, an integrated software platform that supports all stages of targeted, SRM-based proteomics experiments including target selection, transition optimization and post acquisition data analysis. This so

SUBMITTER: Brusniak MY 

PROVIDER: S-EPMC3213215 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature