Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies.

ABSTRACT:

Objective

To investigate the association between intake of dietary fibre and whole grains and risk of colorectal cancer.

Design

Systematic review and meta-analysis of prospective observational studies.

Data sources

PubMed and several other databases up to December 2010 and the reference lists of studies included in the analysis as well as those listed in published meta-analyses.

Study selection

Prospective cohort and nested case-control studies of dietary fibre or whole grain intake and incidence of colorectal cancer.

Results

25 prospective studies were included in the analysis. The summary relative risk of developing colorectal cancer for 10 g daily of total dietary fibre (16 studies) was 0.90 (95% confidence interval 0.86 to 0.94, I(2) = 0%), for fruit

SUBMITTER: Aune D 

PROVIDER: S-EPMC3213242 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature