Statins are associated with reduced use of steroids in inflammatory bowel disease: a retrospective cohort study.

ABSTRACT:

Background

Statin medications have antiinflammatory effects. We sought to determine whether statin use in persons with inflammatory bowel disease (IBD) was associated with reduced rates of steroid use or other markers of disease activity.

Methods

We performed a retrospective cohort study using administrative data. Statin users with IBD were compared to statin-unexposed IBD subjects. The primary outcome was an oral steroid prescription; secondary outcomes included anti-tumor necrosis factor (TNF) initiation, hospitalization, or abdominal surgery. Cox proportional hazard models were used to estimate hazard ratios (HRs) adjusted for potential confounders.

Results

The study cohort included 1986 statin-exposed and 9871 unexposed subjects. Statin use was associated with an

SUBMITTER: Crockett SD 

PROVIDER: S-EPMC3213287 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature