Molecular basis of virulence in Staphylococcus aureus mastitis.

ABSTRACT:

Background

S. aureus is one of the main pathogens involved in ruminant mastitis worldwide. The severity of staphylococcal infection is highly variable, ranging from subclinical to gangrenous mastitis. This work represents an in-depth characterization of S. aureus mastitis isolates to identify bacterial factors involved in severity of mastitis infection.

Methodology/principal findings

We employed genomic, transcriptomic and proteomic approaches to comprehensively compare two clonally related S. aureus strains that reproducibly induce severe (strain O11) and milder (strain O46) mastitis in ewes. Variation in the content of mobile genetic elements, iron acquisition and metabolism, transcriptional regulation and exoprotein production was observed. In particular, O11 produced rel

SUBMITTER: Le Marechal C 

PROVIDER: S-EPMC3214034 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature