A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia.

ABSTRACT:

Background

Preeclampsia is a frequent complication of pregnancy and a leading cause of perinatal mortality. Both genetic and environmental risk factors have been identified. Lipid metabolism, particularly cholesterol metabolism, is associated with this disease. Liver X receptors alpha (NR1H3, also known as LXRalpha) and beta (NR1H2, also known as LXRbeta) play a key role in lipid metabolism. They belong to the nuclear receptor superfamily and are activated by cholesterol derivatives. They have been implicated in preeclampsia because they modulate trophoblast invasion and regulate the expression of the endoglin (CD105) gene, a marker of preeclampsia. The aim of this study was to investigate associations between the NR1H3 and NR1H2 genes and preeclampsia.

Methods

We assessed a

SUBMITTER: Mouzat K 

PROVIDER: S-EPMC3214159 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature