Inverse current source density method in two dimensions: inferring neural activation from multielectrode recordings.

ABSTRACT: The recent development of large multielectrode recording arrays has made it affordable for an increasing number of laboratories to record from multiple brain regions simultaneously. The development of analytical tools for array data, however, lags behind these technological advances in hardware. In this paper, we present a method based on forward modeling for estimating current source density from electrophysiological signals recorded on a two-dimensional grid using multi-electrode rectangular arrays. This new method, which we call two-dimensional inverse Current Source Density (iCSD 2D), is based upon and extends our previous one- and three-dimensional techniques. We test several variants of our method, both on surrogate data generated from a collection of Gaussian sources, and on model d

SUBMITTER: Leski S 

PROVIDER: S-EPMC3214268 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature