Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis.

ABSTRACT: The circadian clock generates daily rhythms in mammalian liver processes, such as glucose and lipid homeostasis, xenobiotic metabolism, and regeneration. The mechanisms governing these rhythms are not well understood, particularly the distinct contributions of the cell-autonomous clock and central pacemaker to rhythmic liver physiology. Through microarray expression profiling in Met murine hepatocytes (MMH)-D3, we identified over 1,000 transcripts that exhibit circadian oscillations, demonstrating that the cell-autonomous clock can drive many rhythms, and that MMH-D3 is a valid circadian model system. The genes represented by these circadian transcripts displayed both cophasic and antiphasic organization within a protein-protein interaction network, suggesting the existence of competition

SUBMITTER: Atwood A 

PROVIDER: S-EPMC3215069 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature