ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro.

ABSTRACT:

Background

Dengue virus (DENV) and West Nile virus (WNV), close siblings of the Flaviviridae family, are the causative agents of Dengue hemorraghic shock or West Nile meningoencephalitis respectively. Vaccines against these two flaviviruses are currently unavailable. Interferon- Stimulated Gene 15 (ISG15), encoding an ubiquitin-like protein, is significantly induced by type I interferons or viral infections. Its roles in viral infections, however, vary with viruses, being either anti- or pro-viral. The exact roles of ISG15 in DENV and WNV infections remain unknown. In the current study, we evaluated the relevancies of ISG15 to DENV and WNV infection of a mouse macrophage cell line RAW264.7.

Findings

Quantitative PCR showed that mouse Isg15 was dramatically induced in DENV or

SUBMITTER: Dai J 

PROVIDER: S-EPMC3215395 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature