Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function.

ABSTRACT:

Background

Fatty acid amide hydrolase (FAAH) is a key enzyme in regulating endocannabinoid (eCB) signaling. A common single nucleotide polymorphism (C385A) in the human FAAH gene has been associated with increased risk for addiction and obesity.

Methods

Using imaging genetics in 82 healthy adult volunteers, we examined the effects of FAAH C385A on threat- and reward-related human brain function.

Results

Carriers of FAAH 385A, associated with reduced enzyme and possibly increased eCB signaling, had decreased threat-related amygdala reactivity but increased reward-related ventral striatal reactivity in comparison with C385 homozygotes. Similarly divergent effects of FAAH C385A genotype were manifest at the level of brain-behavior relationships. The 385A carriers showed

SUBMITTER: Hariri AR 

PROVIDER: S-EPMC3215587 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature