A historical and proteomic analysis of botulinum neurotoxin type/G.

ABSTRACT:

Background

Clostridium botulinum is the taxonomic designation for at least six diverse species that produce botulinum neurotoxins (BoNTs). There are seven known serotypes of BoNTs (/A through/G), all of which are potent toxins classified as category A bioterrorism agents. BoNT/G is the least studied of the seven serotypes. In an effort to further characterize the holotoxin and neurotoxin-associated proteins (NAPs), we conducted an in silico and proteomic analysis of commercial BoNT/G complex. We describe the relative quantification of the proteins present in the/G complex and confirm our ability to detect the toxin activity in vitro. In addition, we review previous literature to provide a complete description of the BoNT/G complex.

Results

An in-depth comparison of protein s

SUBMITTER: Terilli RR 

PROVIDER: S-EPMC3215672 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature