Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen.

ABSTRACT:

Background

The genus Flavivirus encompasses more than 50 distinct species of arthropod-borne viruses, including several major human pathogens, such as West Nile virus, yellow fever virus, Japanese encephalitis virus and the four serotypes of dengue viruses (DENV type 1-4). Each year, flaviviruses cause more than 100 million infections worldwide, some of which lead to life-threatening conditions such as encephalitis or haemorrhagic fever. Among the viral proteins, NS3 and NS5 proteins constitute the major enzymatic components of the viral replication complex and are essential to the flavivirus life cycle.

Results

We report here the results of a high-throughput yeast two-hybrid screen to identify the interactions between human host proteins and the flavivirus NS3 and NS5 prote

SUBMITTER: Le Breton M 

PROVIDER: S-EPMC3215679 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature