Differential proliferation rhythm of neural progenitor and oligodendrocyte precursor cells in the young adult hippocampus.

ABSTRACT: Oligodendrocyte precursor cells (OPCs) are a unique type of glial cells that function as oligodendrocyte progenitors while constantly proliferating in the normal condition from rodents to humans. However, the functional roles they play in the adult brain are largely unknown. In this study, we focus on the manner of OPC proliferation in the hippocampus of the young adult mice. Here we report that there are oscillatory dynamics in OPC proliferation that differ from neurogenesis in the subgranular zone (SGZ); the former showed S-phase and M-phase peaks in the resting and active periods, respectively, while the latter only exhibited M-phase peak in the active period. There is coincidence between different modes of proliferation and expression of cyclin proteins that are crucial for cell cycle;

SUBMITTER: Matsumoto Y 

PROVIDER: S-EPMC3215740 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature