Testing Hardy-Weinberg proportions in a frequency-matched case-control genetic association study.

ABSTRACT: In case-control genetic association studies, cases are subjects with the disease and controls are subjects without the disease. At the time of case-control data collection, information about secondary phenotypes is also collected. In addition to studies of primary diseases, there has been some interest in studying genetic variants associated with secondary phenotypes. In genetic association studies, the deviation from Hardy-Weinberg proportion (HWP) of each genetic marker is assessed as an initial quality check to identify questionable genotypes. Generally, HWP tests are performed based on the controls for the primary disease or secondary phenotype. However, when the disease or phenotype of interest is common, the controls do not represent the general population. Therefore, using only cont

SUBMITTER: Wang J 

PROVIDER: S-EPMC3215743 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature