Ontology highlight
ABSTRACT:
SUBMITTER: Delaney JR
PROVIDER: S-EPMC3215821 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Aging cell 20111003 6
Activation of Sir2 orthologs is proposed to increase lifespan downstream of dietary restriction. Here, we describe an examination of the effect of 32 different lifespan-extending mutations and four methods of DR on replicative lifespan (RLS) in the short-lived sir2Δ yeast strain. In every case, deletion of SIR2 prevented RLS extension; however, RLS extension was restored when both SIR2 and FOB1 were deleted in several cases, demonstrating that SIR2 is not directly required for RLS extension. The ...[more]