Alu pair exclusions in the human genome.

ABSTRACT:

Background

The human genome contains approximately one million Alu elements which comprise more than 10% of human DNA by mass. Alu elements possess direction, and are distributed almost equally in positive and negative strand orientations throughout the genome. Previously, it has been shown that closely spaced Alu pairs in opposing orientation (inverted pairs) are found less frequently than Alu pairs having the same orientation (direct pairs). However, this imbalance has only been investigated for Alu pairs separated by 650 or fewer base pairs (bp) in a study conducted prior to the completion of the draft human genome sequence.

Results

We performed a comprehensive analysis of all (> 800,000) full-length Alu elements in the human genome. This large sample size permits detecti

SUBMITTER: Cook GW 

PROVIDER: S-EPMC3215922 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature