In silico characterization of microbial electrosynthesis for metabolic engineering of biochemicals.

ABSTRACT:

Background

A critical concern in metabolic engineering is the need to balance the demand and supply of redox intermediates such as NADH. Bioelectrochemical techniques offer a novel and promising method to alleviate redox imbalances during the synthesis of biochemicals and biofuels. Broadly, these techniques reduce intracellular NAD+ to NADH and therefore manipulate the cell's redox balance. The cellular response to such redox changes and the additional reducing power available to the cell can be harnessed to produce desired metabolites. In the context of microbial fermentation, these bioelectrochemical techniques can be used to improve product yields and/or productivity.

Results

We have developed a method to characterize the role of bioelectrosynthesis in chemical production

SUBMITTER: Pandit AV 

PROVIDER: S-EPMC3215969 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature