Regulation of the yeast metabolic cycle by transcription factors with periodic activities.

ABSTRACT:

Background

When growing budding yeast under continuous, nutrient-limited conditions, over half of yeast genes exhibit periodic expression patterns. Periodicity can also be observed in respiration, in the timing of cell division, as well as in various metabolite levels. Knowing the transcription factors involved in the yeast metabolic cycle is helpful for determining the cascade of regulatory events that cause these patterns.

Results

Transcription factor activities were estimated by linear regression using time series and genome-wide transcription factor binding data. Time-translation matrices were estimated using least squares and were used to model the interactions between the most significant transcription factors. The top transcription factors have functions involving res

SUBMITTER: Rao AR 

PROVIDER: S-EPMC3216092 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature