Effect of L-carnitine on the hepatic transcript profile in piglets as animal model.

ABSTRACT:

Background

Carnitine has attracted scientific interest due to several health-related effects, like protection against neurodegeneration, mitochondrial decay, and oxidative stress as well as improvement of glucose tolerance and insulin sensitivity. The mechanisms underlying most of the health-related effects of carnitine are largely unknown.

Methods

To gain insight into mechanisms through which carnitine exerts its beneficial metabolic effects, we fed piglets either a control or a carnitine supplemented diet, and analysed the transcriptome in the liver.

Results

Transcript profiling revealed 563 genes to be differentially expressed in liver by carnitine supplementation. Clustering analysis of the identified genes revealed that most of the top-ranked annotation term clus

SUBMITTER: Keller J 

PROVIDER: S-EPMC3216248 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature