Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs.

ABSTRACT: Over a quarter of the U.S. population is exposed to harmful levels of airborne particulate matter (PM) pollution, which has been linked to development and exacerbation of respiratory diseases leading to morbidity and mortality, especially in susceptible populations. Young children are especially susceptible to PM and can experience altered anatomic, physiologic, and biological responses. Current studies of ambient PM are confounded by the complex mixture of soot, metals, allergens, and organics present in the complex mixture as well as seasonal and temporal variance. We have developed a laboratory-based PM devoid of metals and allergens that can be replicated to study health effects of specific PM components in animal models. We exposed 7-day-old postnatal and adult rats to a single 6-h ex

SUBMITTER: Chan JK 

PROVIDER: S-EPMC3216412 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature