Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a meta-analysis.

ABSTRACT:

Background

It has been proposed by Zamboni and colleagues that multiple sclerosis is caused by chronic cerebrospinal venous insufficiency, a term used to describe ultrasound-detectable abnormalities in the anatomy and flow of intra- and extracerebral veins. We conducted a meta-analysis of studies that reported the frequency of chronic cerebrospinal venous insufficiency among patients with and those without multiple sclerosis.

Methods

We searched MEDLINE and EMBASE as well as bibliographies of relevant articles for eligible studies. We included studies if they used ultrasound to diagnose chronic cerebrospinal venous insufficiency and compared the frequency of the venous abnormalities among patients with and those without multiple sclerosis.

Results

We identified eight

SUBMITTER: Laupacis A 

PROVIDER: S-EPMC3216446 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature