Global cross-talk of genes of the mosquito Aedes aegypti in response to dengue virus infection.

ABSTRACT:

Background

The mosquito Aedes aegypti is the primary vector of dengue virus (DENV) infection in humans, and DENV is the most important arbovirus across most of the subtropics and tropics worldwide. The early time periods after infection with DENV define critical cellular processes that determine ultimate success or failure of the virus to establish infection in the mosquito.

Methods and results

To identify genes involved in these processes, we performed genome-wide transcriptome profiling between susceptible and refractory A. aegypti strains at two critical early periods after challenging them with DENV. Genes that responded coordinately to DENV infection in the susceptible strain were largely clustered in one specific expression module, whereas in the refractory strain they

SUBMITTER: Behura SK 

PROVIDER: S-EPMC3216916 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature