The effect of tear size and nerve injury on rotator cuff muscle fatty degeneration in a rodent animal model.

ABSTRACT:

Background

Irreversible muscle changes after rotator cuff tears is a well-known negative prognostic factor after shoulder surgery. Currently, little is known about the pathomechanism of fatty degeneration of the rotator cuff muscles after chronic cuff tears. The purposes of this study were to (1) develop a rodent animal model of chronic rotator cuff tears that can reproduce fatty degeneration of the cuff muscles seen clinically, (2) describe the effects of tear size and concomitant nerve injury on muscle degeneration, and (3) evaluate the changes in gene expression of relevant myogenic and adipogenic factors after rotator cuff tears using the animal model.

Materials and methods

Rotator cuff tears were created in rodents with and without transection of the suprascapular nerve

SUBMITTER: Kim HM 

PROVIDER: S-EPMC3217129 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature