Ontology highlight
ABSTRACT:
SUBMITTER: Albagha OM
PROVIDER: S-EPMC3217192 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Nature genetics 20100502 6
Paget's disease of bone (PDB) is a common disorder with a strong genetic component characterized by focal increases in bone turnover, which in some cases is caused by mutations in SQSTM1. To identify additional susceptibility genes, we performed a genome-wide association study in 750 individuals with PDB (cases) without SQSTM1 mutations and 1,002 controls and identified three candidate disease loci, which were then replicated in an independent set of 500 cases and 535 controls. The strongest sig ...[more]