Antioxidant properties of lutein contribute to the protection against lipopolysaccharide-induced uveitis in mice.

ABSTRACT:

Background

Lutein is an important eye-protective nutrient. This study investigates the protective effects and mechanisms of lutein on lipopolysaccharides (LPS)-induced uveitis in mice.

Methods

Lutein, suspended in drinking water at a final concentration of 12.5 and 25 mg/mL, was administered to mice at 0.1 mL/10 g body weight for five consecutive days. Control and model group received drinking water only. Uveitis was induced by injecting LPS (100 mg per mouse) into the footpad in the model and lutein groups on day 5 after the last drug administration. Eyes of the mice were collected 24 hours after the LPS injection for the detection of indicators using commercial kits and reverse transcription-polymerase chain reaction.

Results

LPS-induced uveitis was confirmed by sig

SUBMITTER: He RR 

PROVIDER: S-EPMC3217882 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature