Incorporating evolutionary information and functional domains for identifying RNA splicing factors in humans.

ABSTRACT: Regulation of pre-mRNA splicing is achieved through the interaction of RNA sequence elements and a variety of RNA-splicing related proteins (splicing factors). The splicing machinery in humans is not yet fully elucidated, partly because splicing factors in humans have not been exhaustively identified. Furthermore, experimental methods for splicing factor identification are time-consuming and lab-intensive. Although many computational methods have been proposed for the identification of RNA-binding proteins, there exists no development that focuses on the identification of RNA-splicing related proteins so far. Therefore, we are motivated to design a method that focuses on the identification of human splicing factors using experimentally verified splicing factors. The investigation of amino

SUBMITTER: Hsu JB 

PROVIDER: S-EPMC3217973 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature