Regional genome transcriptional response of adult mouse brain to hypoxia.

ABSTRACT:

Background

Since normal brain function depends upon continuous oxygen delivery and short periods of hypoxia can precondition the brain against subsequent ischemia, this study examined the effects of brief hypoxia on the whole genome transcriptional response in adult mouse brain.

Result

Pronounced changes of gene expression occurred after 3 hours of hypoxia (8% O(2)) and after 1 hour of re-oxygenation in all brain regions. The hypoxia-responsive genes were predominantly up-regulated in hindbrain and predominantly down-regulated in forebrain - possibly to support hindbrain survival functions at the expense of forebrain cognitive functions. The up-regulated genes had a significant role in cell survival and involved both shared and unshared signaling pathways among different bra

SUBMITTER: Xu H 

PROVIDER: S-EPMC3218040 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature