SProtP: a web server to recognize those short-lived proteins based on sequence-derived features in human cells.

ABSTRACT: Protein turnover metabolism plays important roles in cell cycle progression, signal transduction, and differentiation. Those proteins with short half-lives are involved in various regulatory processes. To better understand the regulation of cell process, it is important to study the key sequence-derived factors affecting short-lived protein degradation. Until now, most of protein half-lives are still unknown due to the difficulties of traditional experimental methods in measuring protein half-lives in human cells. To investigate the molecular determinants that affect short-lived proteins, a computational method was proposed in this work to recognize short-lived proteins based on sequence-derived features in human cells. In this study, we have systematically analyzed many features that perh

SUBMITTER: Song X 

PROVIDER: S-EPMC3218052 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature