Extensive recombination events and horizontal gene transfer shaped the Legionella pneumophila genomes.

ABSTRACT:

Background

Legionella pneumophila is an intracellular pathogen of environmental protozoa. When humans inhale contaminated aerosols this bacterium may cause a severe pneumonia called Legionnaires' disease. Despite the abundance of dozens of Legionella species in aquatic reservoirs, the vast majority of human disease is caused by a single serogroup (Sg) of a single species, namely L. pneumophila Sg1. To get further insights into genome dynamics and evolution of Sg1 strains, we sequenced strains Lorraine and HL 0604 1035 (Sg1) and compared them to the available sequences of Sg1 strains Paris, Lens, Corby and Philadelphia, resulting in a comprehensive multigenome analysis.

Results

We show that L. pneumophila Sg1 has a highly conserved and syntenic core genome that comprises the

SUBMITTER: Gomez-Valero L 

PROVIDER: S-EPMC3218107 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature