Functional connectivity tracks clinical deterioration in Alzheimer's disease.

ABSTRACT: While resting state functional connectivity has been shown to decrease in patients with mild and/or moderate Alzheimer's disease, it is not yet known how functional connectivity changes in patients as the disease progresses. Furthermore, it has been noted that the default mode network is not as homogenous as previously assumed and several fractionations of the network have been proposed. Here, we separately investigated the modulation of 3 default mode subnetworks, as identified with group independent component analysis, by comparing Alzheimer's disease patients to healthy controls and by assessing connectivity changes over time. Our results showed decreased connectivity at baseline in patients versus controls in the posterior default mode network, and increased connectivity in the anterio

SUBMITTER: Damoiseaux JS 

PROVIDER: S-EPMC3218226 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature