Impaired mitochondrial biogenesis precedes heart failure in right ventricular hypertrophy in congenital heart disease.

ABSTRACT:

Background

The outcome of the surgical repair in congenital heart disease correlates with the degree of myocardial damage. In this study, we determined whether mitochondrial DNA depletion is a sensitive marker of right ventricular (RV) damage and whether impaired mitochondrial DNA (mtDNA) replication contributes to the transition from compensated hypertrophy to failure.

Methods and results

RV samples obtained from 31 patients undergoing cardiac surgery were compared with 5 RV samples from nonfailing hearts (control). Patients were divided into compensated hypertrophy and failure groups, based on preoperative echocardiography, catheterization, and/or MRI data. Mitochondrial enzyme activities (citrate synthase and succinate dehydrogenase) were maintained during hypertrophy and

SUBMITTER: Karamanlidis G 

PROVIDER: S-EPMC3218261 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature