Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis.

ABSTRACT: AccD6 (acetyl coenzyme A (CoA) carboxylase), plays an important role in mycolic acid synthesis of Mycobacterium tuberculosis (Mtb). Induced gene expression by isoniazid (isonicotinylhydrazine - INH), anti-tuberculosis drug) shows the expression of accD6. It is our interest to study the binding of activated INH with the AccD6 model using molecular docking procedures. The study predicts a primary binding site for activated INH (isonicotinyl acyl radical) in AccD6 as a potential target.

SUBMITTER: Unissa AN 

PROVIDER: S-EPMC3218310 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature