An improved hybrid of SVM and SCAD for pathway analysis.

ABSTRACT: Pathway analysis has lead to a new era in genomic research by providing further biological process information compared to traditional single gene analysis. Beside the advantage, pathway analysis provides some challenges to the researchers, one of which is the quality of pathway data itself. The pathway data usually defined from biological context free, when it comes to a specific biological context (e.g. lung cancer disease), typically only several genes within pathways are responsible for the corresponding cellular process. It also can be that some pathways may be included with uninformative genes or perhaps informative genes were excluded. Moreover, many algorithms in pathway analysis neglect these limitations by treating all the genes within pathways as significant. In previous study,

SUBMITTER: Misman MF 

PROVIDER: S-EPMC3218518 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature